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Earnings call: Trevi Therapeutics reports Q3 2024 financials, clinical updates

EditorAhmed Abdulazez Abdulkadir
Published 11/08/2024, 07:05 AM
TRVI
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Trevi Therapeutics, Inc. (NASDAQ: NASDAQ:TRVI) discussed its third-quarter financial results and provided updates on its clinical trials, including the anticipated milestones for its drug Haduvio, during its earnings call on September 30, 2024. The company reported a net loss of $13.2 million for Q3 2024, an increase from the previous year's $7.7 million.

Research and development (R&D) expenses were up, reflecting ongoing clinical trials for Haduvio in treating chronic cough associated with idiopathic pulmonary fibrosis (IPF) and refractory chronic cough (RCC). As of September 30, 2024, Trevi had $65.5 million in cash and equivalents, with a projected cash runway extending into the second half of 2026.

Key Takeaways

  • Trevi Therapeutics reports a Q3 2024 net loss of $13.2 million, with R&D expenses at $11.2 million.
  • The company's cash and equivalents stand at $65.5 million, expected to last into the second half of 2026.
  • Clinical trial updates include the CORAL Phase 2b trial for IPF chronic cough and the RIVER trial for RCC, with key data readouts expected by the first half of 2025.
  • The Human Abuse Potential (HAP) study for injectable nalbuphine is expected to deliver results in December 2024.
  • The TIDAL study is enrolling patients to define the Phase 3 population for IPF, with results anticipated before the end of Phase 2 meeting in the second half of 2025.

Company Outlook

  • Trevi is focused on advancing its clinical trials and expects significant data readouts in the near future.
  • The company's financial position is stable, with sufficient funds to support operations well into 2026.

Bearish Highlights

  • The net loss increased significantly from Q3 2023 to Q3 2024.
  • Cash and equivalents have decreased from $83 million at the end of 2023 to $65.5 million as of September 30, 2024.

Bullish Highlights

  • Trevi is progressing with key clinical trials, potentially leading to new treatments for chronic cough and IPF.
  • The company has a clear plan for the development and potential approval of Haduvio.

Misses

  • There were no specific "misses" mentioned in the provided context.

Q&A Highlights

  • CEO Jennifer Good discussed the importance of the TIDAL study for future decision-making and the ongoing clinical trial for nalbuphine.
  • Questions from Brandon Folkes and Ryan Deschner focused on the TIDAL study's patient enrollment and the DEA's timeline for decision-making post-HAP study results.
  • The butorphanol dose for the study is set at 6 mg infused over an hour.

Trevi Therapeutics continues to make strides in its clinical development programs, with a focus on bringing new treatment options to patients with chronic cough and IPF. Despite the increased net loss and reduced cash reserves, the company remains optimistic about its future, with several key data readouts on the horizon that could shape the trajectory of its lead drug candidate, Haduvio. Investors and stakeholders will be watching closely as Trevi advances through these critical phases of clinical research and regulatory processes.

InvestingPro Insights

Trevi Therapeutics' financial position and market performance offer additional context to the company's recent earnings report and clinical trial updates. According to InvestingPro data, Trevi's market capitalization stands at $209.06 million, reflecting investor interest in the company's potential despite its current unprofitability.

An InvestingPro Tip highlights that Trevi holds more cash than debt on its balance sheet, which aligns with the company's reported $65.5 million in cash and equivalents. This strong liquidity position supports the projected cash runway into the second half of 2026, providing a financial cushion for ongoing clinical trials.

However, another InvestingPro Tip indicates that Trevi is quickly burning through cash, which is consistent with the increased R&D expenses and net loss reported in Q3 2024. This rapid cash burn underscores the importance of the company's upcoming clinical milestones and potential data readouts in sustaining investor confidence.

Despite these financial challenges, Trevi has shown impressive market performance. The company's year-to-date price total return stands at a remarkable 131.34%, with a one-year return of 103.28%. This strong performance suggests that investors are optimistic about Trevi's pipeline and potential future success.

It's worth noting that InvestingPro offers 10 additional tips for Trevi Therapeutics, providing a more comprehensive analysis for investors interested in deeper insights into the company's financial health and market position.

Full transcript - Trevi Therapeutics Inc (TRVI) Q3 2024:

Operator: Good afternoon, and welcome to the Trevi Therapeutics Third Quarter 2024 Earnings Conference Call. At this time, all participants will be in listen-only mode. [Operator Instructions] After today's presentation, there will be an opportunity to ask questions. [Operator Instructions] Please note this event is being recorded. Various remarks that management makes during this conference call about the company's future expectations, plans and prospects constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by these forward-looking statements as a result of various important factors including those discussed in the Risk Factors section of the company's most recent quarterly report on Form 10-Q, which the company filed with the SEC this afternoon. In addition, any forward-looking statements represent the company's views only as of today and should not be relied upon as representing the company's views as of any subsequent date. While the company may elect to update these forward-looking statements at some point in the future, the company specifically disclaims any obligation to do so even if its views change. I would now like to turn the conference call over to Jennifer Good, Trevi’s President and CEO. Please go ahead.

Jennifer Good: Good afternoon, and thank you for joining us for our third quarter 2024 earnings call and business update. Joining me today on this call are my colleagues, Lisa Delfini, Trevi’s Chief Financial Officer; and Dr. James Cassella, Trevi’s Chief Development Officer. I will give an update on our trials and upcoming data milestones and Lisa will give a brief financial update. Then the three of us are happy to answer any questions. First, I would like to take a minute and introduce you to Jim Cassella, who has recently joined our leadership team as our Chief Development Officer. As some of you may know, Jim has been on our Board of Directors for the past four years and has been a valuable advisor to me in that role. Jim has a deep background in neuroscience drug development with over 35 years working specifically on CNS therapies. Prior to joining Trevi, Jim served as CDO for Concert Pharmaceuticals, which was acquired by Sun Pharma in 2023, where he led the development activities, resulting in the successful U.S. FDA approval of the autoimmune JAK inhibitor Leqselvi. Prior to joining Concert, Jim was EVP, Research and Development and CSO at Alexza Pharmaceuticals from 2004 to 2015 where he was responsible for the U.S. and European approval of the CNS drug Adasuve. Jim received a PhD in Physiological Psychology from Dartmouth College and completed a postdoctoral fellowship in the Department of Psychiatry at the Yale School of Medicine. Jim brings a wealth of development experience to Trevi, including Phase 3 and recent regulatory approval experience, which will be invaluable as we advance into late-stage development. He joins Trevi at an exciting time as we read out important studies over the upcoming months and prepare for Phase 3 pivotal trials and NDA submission. So welcome Jim. This has been a very productive quarter at Trevi, as we continue to execute against our clinical development plans for both patients with chronic cough and idiopathic pulmonary fibrosis, or IPF, as well as patients with refractory chronic cough or RCC. We have a number of upcoming data readouts and we hope to build on the strong efficacy we saw in our Phase 2a trial in patients with IPF chronic cough. As we have advanced the clinical development in our two programs, there have been continued failures with competitors’ products in both disease modification trials in IPF, as well as drugs being studied in RCC, reminding us of the continued need for new therapies for patients suffering from these serious conditions. I will run through an update on our upcoming clinical data readouts which I believe are seminal in value creation for the company. I will discuss them in order of timing. First up, the Human Abuse Potential, or HAP study. I have discussed this extensively with investors and analysts, so I'm sure you all feel you know more about HAP studies than you ever cared to. So let me summarize the key points on HAP as we prepare for data. As a reminder, injectable nalbuphine, which is indicated for severe pain has been around for decades and has remained unscheduled by the DEA. The DEA looks at scheduling of molecules regularly and schedules drugs based on the chemical entity, not the delivery mechanism. As recently as 2023, the date of their last review, the DEA has kept nalbuphine unscheduled. Importantly, I wanted to summarize for you their reasonings in their recent opinion. First is nalbuphine's unique mechanism of action. Nalbuphine is a kappa agonist and mu antagonist or KAMA, which is in the class of mixed agonist-antagonist drugs. All drugs that are either a kappa agonist or a mu antagonist are unscheduled and these were designed to mitigate abuse potential. Second, nalbuphine is less attractive to abusers, due to its potent antagonistic effects at mu, which precipitate drug withdrawal. Third, even though nalbuphine is currently available, the DEA cites that nalbuphine is rarely encountered by law enforcement personnel or submitted to forensic labs for analysis. So there's a lot of history with nalbuphine as a molecule and it is not new to the DEA. So why are we doing the HAP study at all? There is FDA guidance from 2017 that requires HAP studies for all CNS active drugs, so we are bringing the package up to current day standards. Finally, this study will be reviewed by the Controlled Substance Staff, CSS, a group in FDA as part of the Eight Factor plan. The Eight Factor plan has several categories of which only one is the HAP. So we will wait to see the final data, but we believe there are a lot of reasons why nalbuphine will remain unscheduled if approved in chronic cough. Okay, moving on to our clinical indications. Next (LON:NXT) up for data will be the sample size re-estimation in our IPF cough trial. First, I want to note that new treatment options for IPF patients have been scarce since the antifibrotics were approved 10 years ago and neither of the two approved antifibrotics have shown significant reduction in chronic cough. Second, other than our Phase 2 data there have not been any successful trials in IPF cough despite being one of the primary complaints by these patients. And third, we believe cough may be a risk factor that plays a role in the progression of the underlying disease. The constant lung injury, micro tears and potential inflammation caused by persistent coughing may lead to worse health outcomes for patients such as increased respiratory hospitalizations, mortality or need for transplant. So we continue to believe our program is important to these patients, their loved ones and doctors. Our IPF chronic cough trial CORAL is a Phase 2b parallel arm dose ranging study that will investigate three active doses of Haduvio and placebo. The study is a six week trial in approximately 160 patients. The next milestone in CORAL is to conduct the sample size re-estimation, SSRE analysis when 50% of the patients complete the study. This analysis will be done by an unblinded statistician external to the company who will rerun the power calculations using actual data. We will get very limited information back, but will be informed of one of the following three outcomes. One, continue on with the planned 160 patients, which will reconfirm the original powering assumptions, two, the drug is working within the pre-specified promising zone, but will require an upsize in the number of patients to maintain the power, or three, the drug is not working in the pre-specified range and the company should consider stopping or futility. We will announce the results of this analysis when we have the information which we expect in December of this year. We continue to expect top line data for the full study in the first half of 2025 subject to the outcome of the SSRE. From my perspective, the SSRE is a key de-risking event for the ultimate success of this trial, if the answer back is anything but futility. The statistical range in this study, both the original N as well as the upper limit of the range is aligned to a clinically meaningful placebo adjusted change. So it is just a matter of figuring out the right sample size in this study population. Following the SSRE and IPF cough, we expect data in the first quarter of 2025 for our phase 2a RIVER trial in RCC. RCC is a debilitating disease that affects approximately 2 million to 3 million U.S. adults and is defined as a persistent cough lasting greater than eight weeks, despite treatment for an underlying condition or where no underlying condition exists. With a lack of any approved therapies for RCC in the U.S. and several drug candidate failures, there continues to be a significant unmet need and an urgency from patients and providers for new mechanisms. Although there have been many failures in RCC drug development, we believe our unique central and peripheral mechanism could change that outcome. The many drugs that have failed have all been peripheral only agents. The types of cough we are studying are linked through hypersensitivity in the brain and this is why we believe our mechanism may be important in this condition. Our RCC trial is a Phase 2a crossover design that has been conducted in several cough trials across the industry and was designed to enroll approximately 60 patients. These patients were randomized to nalbuphine or placebo, with patients stratified by cough count. Those with 10 to 19 coughs per hour moderate cough and those with greater than or equal to 20 coughs per hour high cough. The primary analysis will be conducted on the total population, but we will have the ability to understand if our drug shows its signal in these moderate coughers where other programs have been unsuccessful. This trial is now fully enrolled with the last patient out at the beginning of 2025. We are excited to complete this study and report the data for this significant chronic cough condition in Q1 of 2025. As you can see, we made a lot of progress over the last few months on completing enrollment and dosing and are eager to see the data from each of these trials. To summarize, we expect HAP data in December of this year, followed by CORAL Phase 2b SSRE by year end as well. Then looking into 2025, we expect RIVER Phase 2a top line data in Q1 2025, then the top line data from the full CORAL Phase 2b study in first half 2025, assuming no increase in the sample size. This is an exciting time at Trevi with strong news flow in the upcoming months, all representing important value inflection points. I will now turn it over to Lisa to review our financial results.

Lisa Delfini: Thank you, Jennifer and good afternoon everyone. The full financial results for the three months ended September 30, 2024 can be found in our press release issued ahead of this call and our 10-Q, which was filed with the SEC today after the market closed. For the third quarter of 2024, we reported a net loss of $13.2 million compared to a net loss of $7.7 million for the same quarter in 2023. R&D expenses were $11.2 million during the third quarter of 2024 compared to $6.3 million in the same quarter of 2023. The increase in R&D spend reflects the significant clinical development activity Jennifer just discussed, including continued enrollment in our CORAL trial in chronic cough and IPF, the final full quarter of enrollment in the RIVER trial in RCC, and the final full quarter of dosing in the HAP trial. G&A expenses were $2.9 million during the third quarter of 2024 compared to $2.7 million in the same period of 2023, primarily due to an increase in stock-based compensation expense and importantly demonstrating the control of overhead expenses, which we continue to be mindful of. As of September 30, 2024, our cash, cash equivalents and marketable securities totaled $65.5 million compared to $83 million as of December 31, 2023. Our current expectation is that our cash burn for 2024, excluding proceeds from share issuances and interest and investment income, will be between $41 million and $43 million in line with our previous guidance. We now project cash runway into the second half of 2026, more than a year past all current projected data readouts. This concludes our prepared remarks. I will now turn the call back over to the operator for Q&A.

Operator: Thank you. [Operator Instructions] And the first question will be from Faisal Khurshid from Leerink. Please go ahead.

Faisal Khurshid: Hey everyone, thank you for taking the question. Also, just wanted to say welcome to Jim and congrats on the new hire. So for the…

James Cassella: Thanks so much.

Faisal Khurshid: Yes. And since on the half, can you clarify, like, what is your expectation for butorphanol drug liking and what's the evidence that supports that? And also totally hear your point that drug scheduling considers the entire eight factor analysis. But what do you want to see from nalbuphine in the HAP to support an unscheduled designation as opposed to a potential Schedule IV?

Jennifer Good: Thank you, Faisal. I'm going to let Jim go ahead and take that.

James Cassella: Yes. So thank you. It's nice to meet you and pleasure to be here for sure. So, these are complicated studies and they involve, experts running these things with subjects who have experience with the drug. Butorphanol is a drug that is scheduled for and has been abused by subjects. So we don't think we're – well, we have to have patients qualify or subjects qualify to get into the study with butorphanol in a qualification period. So we are setting limits on their entry into the study where they have to have a certain criteria reached in an absolute sense, as well as having a differentiation from placebo. So we know we're going to have effects on butorphanol or from butorphanol in the study, and that is the part of the protocol that has been approved by the FDA. So when we look at this study and it's in the context of looking at scheduling in total, at the end of the day, this study is really designed to look at a number of things. With the primary endpoint, which is the VAS drug liking scale. We're looking to determine study validity by showing that butorphanol does differentiate from placebo and there's a fixed criteria of at least 15 points for that. We'll be looking at the relative abuse liability in terms of nalbuphine versus butorphanol, and in that, we'll be able to see if there is a lower relative abuse potential for nalbuphine by pre-specified statistical endpoints determined and approved by the review by the FDA. And importantly, we'll be looking at the absolute abuse potential for nalbuphine in relationship to placebo. So in that case we are able to determine within an equivalence margin that has been preset and again reviewed and approved by the FDA of 11 points within the placebo arm. We'll be able to determine for each dose whether or not we are significantly within that 11 point range from placebo. And if we are, then we'll be able to make a statement that we do not produce an abuse related signal compared to placebo. So those are the three outcomes using the primary efficacy endpoint of drug liking. And we'll be able to take it from there as we look at the further evidence from the other endpoints in the study and put that in relationship to the whole package that we'll need to put in front of the FDA. That includes other things like experience from our other clinical trials and the other things that Jennifer has referred to from the most recent DSS [ph] analysis of nalbuphine.

Faisal Khurshid: Got it. That's helpful. Thank you.

Operator: And the next question will be from Leland Gershell from Oppenheimer. Please go ahead.

Leland Gershell: Hey, thanks for the update, and my welcome to Jim as well. Thanks for taking the questions. I'll try to keep it to one, but maybe a multi-part. Jen, just wanted to ask, with respect to the SSRE, would there be a fixed increase in sample size that could be triggered if that's the outcome? Or would it be variable depending on how much you may need to prospectively increase the number of patients given what's been seen and have you shared what the fixed number would be if that's the case? Thank you.

Jennifer Good: Yes. No, it's a good question, Leland. Thank you. So basically, the range that we pre-specified for the SSRE is the original N of 160 and it can go up to a total N of 400. It is not a fixed increase. They're going to take the actual number seen through 50%, repower the study and give us an exact number. So it can be anywhere in that range between 160 and 400 that they would come back with.

James Cassella: And maybe just one other comment on that. So we will be looking at the conditional probability of our findings and then we'll be able to power up based on that. And again it will be a sliding scale depending on what the conditional probability is that is determined by the SSRE.

Leland Gershell: Thank you. I'll jump back in the queue.

Jennifer Good: Thanks, Leland.

Operator: The next question comes from Deb Chatterjee from JonesTrading. Please go ahead.

Deb Chatterjee: Hi. Thanks for taking my question. I might have missed it, but could you please confirm that in the RCC trial, the two arms, like of different degree of coughers are now balanced?

Jennifer Good: Thanks, Debanjana for the question. So she's asking about if they're both balanced, the two arms in the RCC trial since we finished enrollment.

James Cassella: Yes. Balanced in terms of the treatment assignment?

Jennifer Good: I think she's talking about the stratification, one to one.

James Cassella: The stratification, yes. Sure. So the intention was to open up the trial to patients that were stratified on a cough count of 10 to 19 or greater than 20. We did increase the enrollment period to try to get more subjects in the moderate arm. We decided that we were going to cut it off at a certain point in time and not wait for the complete balancing. So – and balancing the complete enrollment of that stratification factor. It doesn't really impact the overall analysis because the overall analysis is based on the number of people in the trial and not based on these subgroup analyses. So we're not concerned about that at all. And I think that it will be sufficient numbers in that group to allow us to look at future-looking, statistical analyses and planning for our greater – the Phase 2b or Phase 3 program. But I think we'll have sufficient numbers in there and that's why we decided to stop when we did.

Deb Chatterjee: Okay. Thanks for the color.

James Cassella: Sure.

Jennifer Good: Thanks, Debanjana and we're looking forward to your call.

Operator: And our next question is from Mayank Mamtani from B. Riley. Please go ahead.

William Wood: Hi. This is William Wood on for Mayank today. Thank you for taking our questions, and congrats on the strong Q. So just to sort of continue on with the HAP trial. I'm just kind of curious what would happen after you receive the results from the trial, maybe the next steps. Would you – essentially would you go directly to the FDA with those results? Or would this sort of be wrapped into a larger midyear 2025 end of Phase 2 meeting?

Jennifer Good: I'll start with that, William and Jim is obviously just joining us. So he may bring some different views. But we'll obviously get the data. We'll end up submitting the CSR and the results around that. We'll, for sure, discuss it in our end of Phase 2 meeting on the IPF trial and probably invite any comments back. But I would envision that we'll wrap that into our next FDA meeting. But we'll submit the results ahead of time. Jim anything?

James Cassella: Absolutely. I mean, it's a standard type study for drugs like this. We'll submit the CSR and all the data to the FDA per usual timing. And this study doesn't really gate us in terms of looking at future efficacy studies in our indications. So this would be a matter of more NDA than the process of actually conducting our clinical programs.

William Wood: Okay, so it wouldn't affect any of the ongoing trials either, just to confirm?

James Cassella: No.

Jennifer Good: No.

James Cassella: No. And again, this is a one of many piece of information that is really weighed by the DEA in general. And I think we just want everyone to remember that nalbuphine has been around for decades. It is unscheduled. It is the moiety, as Jennifer said, that is usually considered. That is considered in the terms of scheduling. So this is a different formulation. We are catching up on bringing a half data into the realm for nalbuphine. So again, all these things are going to be taken into account as well as the experiences of our subjects in our clinical trial. So, there's nothing here that is necessarily gating and these will all be taken into account in the NDA process for approval.

William Wood: Thank you very much. I appreciate you taking your questions.

Jennifer Good: Thank you, William.

Operator: The next question comes from Brandon Folkes from Rodman & Renshaw. Please go ahead.

Brandon Folkes: Hi. Thanks for taking my questions and congratulations on the updates. Maybe just one from me. Any update on the timing of the TIDAL respiratory physiology study? When can we care more about that study? And maybe the second part of that with Jim coming in. Welcome, Jim, great to have you on board. But do you still intend to run that study? Is this something that may be under review? Just any color on commitment and timing to that TIDAL study would be great. Thank you.

Jennifer Good: Yes, I'll comment on the first two and then I'll let Jim answer. I don't think he has any different thoughts. So, Brandon, as you know, we're running this study really just to be able to define our Phase 3 patient population and IPF specifically. There's a group of patients that had sleep disordered breathing that we've carved out in our prior two clinical studies because we wanted to answer some questions around that. So we are – that study is enrolling, it's screening patients enrolling. The timing is, we need that data by the time we go to our end of Phase 2 meeting on IPF, which will be sometime on the current schedule, second half of next year. I think it's unblinded. I don't anticipate that. We'll probably put out a lot of data until we get to the end and we actually can interpret all the results and sort of what it means for our inclusion exclusion. But Jim, I'll let you add any color. I don't think you have any different thoughts.

James Cassella: No, there's no different thoughts there at all. I think this is a good, informative study for us that will just help us make some decisions in the future.

Brandon Folkes: Thanks. And that's great to hear. Thank you for taking the question.

Jennifer Good: Yes, thank you. Brandon.

Operator: [Operator Instructions] The next question is from Ryan Deschner from Raymond (NS:RYMD) James. Please go ahead.

Ryan Deschner: Hi there. I'm curious as to the timeline for DEA to make a decision in that, sort of once you have the HAP results in hand, their decision or even feedback from them on the potential for scheduling. And also curious what dose level to comparator butorphanol is being dosed at. Thank you.

Jennifer Good: Yes, no, I can answer both those. The DEA process unfortunately comes in the end, if it comes at all. What happens is you submit your NDA. FDA will review all that with a consult with CSS [ph]. Sometimes it doesn't even get referred to DEA. They sort of consider everything. Look at your data that you submitted and it never even goes to DEA. If it does, it goes as part of the NDA process and then they'll schedule it as part of your approval. So it'll come sort of right after that. As for the dose that we're using in butorphanol, it's a 6 milligram infusion over the course of an hour. And there was a whole study that was done to sort of mimic the inhaled version of butorphanol that's on the market. We couldn't use that because that actually had a taste to it. So it was very hard to blind it. And so we ended up basically mimicking the PK of that through the 6 milligram infusion. But that was all signed off with the FDA as the right dosed.

Ryan Deschner: Got it. Thank you very much.

Jennifer Good: Yes, you're welcome. Thank you.

Operator: And I'm not showing any further questions at this time. This concludes our question-and-answer session. I would like to turn the conference back over to Jennifer Good for closing remarks.

Jennifer Good: Thank you. We look forward to sharing the results of our various clinical trials with you in the near future. Thank you for joining today's call and we are available after this call for any follow up questions you may have.

Operator: The conference call has now concluded. Thank you for attending today's presentation. You may now disconnect.

This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.

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