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Sanofi Genzyme commits to develop and commercialize hemophilia candidate with Alnylam

Published 11/14/2016, 09:25 AM
Sanofi Genzyme commits to develop and commercialize hemophilia candidate with Alnylam
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  • Alnylam Pharmaceuticals (NASDAQ:ALNY) announces that global alliance partner Sanofi (PA:SASY) Genzyme (NYSE:SNY) will opt-in to co-develop and co-commercialize RNAi therapeutic fitusiran for the treatment of hemophilia and rare bleeding disorders in the U.S., Canada and Western Europe. Sanofi Genzyme had previously elected to exclusively develop fitusiran in their rest-of-world territories. A Phase 3 study is on tap to commence in early 2017.
  • Under the terms of the alliance, Alnylam will receive up to $75M in development and regulatory milestones, including $25M upon the initiation of the Phase 3 trial. It will also earn tiered royalties up to 20% on fitusiran sales in Sanofi Genzyme's exclusive territory. Profits will be shared equally in the co-commercialization territory.
  • Sanofi Genzyme has elected to pass on ALN-AS1, an investigational RNAi therapeutic for acute hepatic porphyrias.
  • The companies formed their alliance in January 2014 to accelerate and expand the development and commercialization of RNAi therapeutics worldwide.

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