SAN FRANCISCO - Nurix Therapeutics, Inc. (NASDAQ:NRIX), a biopharmaceutical company, has unveiled findings from a study demonstrating that its investigational drug NX-2127 can degrade BTK in patients with chronic lymphocytic leukemia (CLL) irrespective of mutation status. This discovery, published in the journal Science, suggests a potential new treatment avenue for those with B-cell malignancies who have developed resistance to existing BTK inhibitors.
The research, conducted in collaboration with various cancer research centers, identified kinase-impaired BTK mutations that maintain oncogenic activity through scaffolding, which sustains B-cell receptor signaling and malignant B-cell growth. NX-2127, an orally bioavailable targeted protein degrader, has shown efficacy in degrading these resistant mutations.
Alexey Danilov, M.D., Ph.D., at the City of Hope National Medical Center, emphasized the importance of these findings for the development of mutation-agnostic treatments, potentially improving outcomes for patients with B-cell malignancies.
Nurix's Chief Scientific Officer, Gwenn M. Hansen, Ph.D., stated that the data reinforce the utility of targeted protein degradation over inhibition approaches to more effectively block BTK function and combat acquired resistance.
The ongoing Phase 1 clinical trial of NX-2127 is focused on patients with relapsed and refractory B-cell malignancies, including CLL. Expansion cohorts are now being initiated for patients with diffuse large B cell lymphoma (DLBCL) and mantle cell lymphoma (MCL).
Additionally, a contemporaneous Drug Annotation manuscript in The Journal of Medicinal Chemistry details the discovery and preclinical pharmacology of NX-2127, supporting its clinical testing advancement.
Nurix is also evaluating NX-5948, another BTK degrader, in a separate Phase 1 clinical trial for similar indications. These developments signal a potential shift in the treatment landscape for B-cell malignancies, with BTK degraders poised to become a significant class of therapeutic agents.
This report is based on a press release statement from Nurix Therapeutics, Inc.
InvestingPro Insights
Nurix Therapeutics, Inc. (NASDAQ:NRIX) has been making significant strides in the development of its BTK degraders, which could potentially revolutionize the treatment of B-cell malignancies. While the scientific community is closely watching the clinical progress, investors are equally attentive to Nurix's financial health and market performance. According to InvestingPro data, Nurix has a market capitalization of $395.31 million and is currently not profitable, with a negative P/E ratio of -2.98 as of Q3 2023. However, revenue has seen a substantial uptick, growing by 74.85% over the last twelve months as of Q3 2023, indicating a robust increase in sales.
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