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MyoKardia up 35% premarket on positive mavacamten results

Published 08/07/2017, 09:11 AM
© Reuters.  MyoKardia up 35% premarket on positive mavacamten results
MYOK
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  • Thinly traded MyoKardia (NASDAQ:MYOK) is up 35% premarket on increased volume in response to its announcement of positive results from the first cohort in a Phase 2 clinical trial, PIONEER-HCM, assessing mavacamten (MYK-461) in patients with symptomatic obstructive hypertrophic cardiomyopathy.
  • All the patients in the cohort (n=10) experienced a statistically valid reduction in post-exercise peak left ventricular outflow tract (LVOT) gradient from baseline to week 12.
  • The Independent Data Monitoring Committee has recommended the continuation of the study.
  • The company intends to advance mavacamten into a pivotal study, EXPLORER-HCM, by year-end.
  • Mavacamten is an orally available small molecule designed to reduce left ventricular contractility by modulating the function of cardiac myosin, the protein that drives heart muscle contraction.
  • Now read: Bioverativ: What A Pipeline


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