In the 2023 Year-End Conference Call and Webcast, Moleculin Biotech (NASDAQ:MBRX) highlighted the progress of Annamycin, its promising drug candidate for Acute Myeloid Leukemia (AML). The company reported a 60% complete remission rate in second line AML patients treated with Annamycin, emphasizing the absence of cardiotoxicity, which is a common issue with similar treatments.
Moleculin is preparing for a pivotal registration study and is seeking accelerated approval. With approximately $24 million in cash, the company plans to sustain operations until the fourth quarter and is taking steps to maintain its NASDAQ listing.
Key Takeaways
- Annamycin shows a 60% complete remission rate in AML second line patients with no observed cardiotoxicity.
- Moleculin plans a pivotal registration study for Annamycin and aims for accelerated approval.
- The company has sufficient cash to last until Q4, with efforts to meet NASDAQ's minimum bid price requirement.
- Plans to form a science advisory board and establish market exclusivity for Annamycin are underway.
- Moleculin is also considering Annamycin for other indications, with Phase 3 readiness highlighted.
Company Outlook
- Moleculin is focused on advancing Annamycin through clinical trials and regulatory processes.
- The company intends to meet with the FDA by early summer to discuss approval pathways.
- A science advisory board is being formed to bolster the drug's development strategy.
Bearish Highlights
- One patient death from pneumonia was reported due to non-compliance with prophylactic therapy.
- The company's market cap is around $20 million, indicating a need for careful financial management.
Bullish Highlights
- Moleculin expressed confidence in Annamycin's potential and its ability to address a significant unmet medical need in AML.
- The company is also exploring Annamycin's use in soft tissue sarcoma and other indications.
Misses
- There is a need to maintain the NASDAQ listing by meeting the minimum $1 bid price.
- The company must carefully manage its cash reserves to ensure continued operation through the year.
Q&A Highlights
- The company has not encountered safety issues with Annamycin and believes a safe and effective dose has been identified.
- Moleculin anticipates confirmation from the FDA for the Phase 3 trial dosage in June.
- The company's primary goal is to achieve FDA approval in a timely and cost-effective manner.
InvestingPro Insights
Moleculin Biotech (MBRX) has been navigating a challenging financial landscape, as reflected in the real-time data from InvestingPro. With a market capitalization of just $11.29 million and a negative price-to-earnings (P/E) ratio of -0.34, the company's financial health is a concern for investors. The negative P/E ratio, which worsened to -0.39 over the last twelve months as of Q4 2023, indicates that the company is not currently generating profit relative to its share price.
The InvestingPro Tips provide further insight into Moleculin's situation. The company holds more cash than debt, which is a positive sign for its liquidity position. However, this is tempered by the fact that Moleculin is quickly burning through its cash reserves, which could pose a risk to its operations if not managed carefully. Additionally, with weak gross profit margins and analysts not expecting profitability this year, the financial outlook remains cautious.
Investors should note that the stock has taken a significant hit, with a 30.85% decline over the last week alone. Over the last three months, the price has fallen by 44.07%, highlighting a sustained downward trend in the market's valuation of the company.
For those considering an investment in Moleculin Biotech, it may be valuable to explore the full list of 11 InvestingPro Tips available on the platform. These insights could provide a more comprehensive understanding of the company's financial health and future prospects. To access these insights, use the coupon code PRONEWS24 to get an additional 10% off a yearly or biyearly Pro and Pro+ subscription at InvestingPro.
Full transcript - Moleculin Biotech Inc (MBRX) Q4 2023:
Operator: Greetings, welcome to the Moleculin Biotech 2023 Year-End Conference Call and Webcast. [Operator Instructions] Please note, that this conference is being recorded. I'd now turn the conference over to Jenene Thomas, Investor Relations. Thank you. You may begin.
Jenene Thomas: Thank you, Gerald. Good morning, and welcome everyone. At this time, I would like to remind our listeners that remarks made during this webcast may state management's intentions, beliefs, expectations, or future projections. These are forward-looking statements and involve risks and uncertainties. Forward-looking statements on this call are made pursuant to the safe harbor provisions of the federal securities laws and are based on Moleculin's current expectations and actual results could differ materially. As a result, you should not place undue reliance on any forward-looking statements. Some of the factors that could cause actual results to differ materially from these contemplated by such forward-looking statements are discussed in the periodic reports, Moleculin files with the Securities and Exchange Commission. These documents are available in the Investors section of the company's website and on the Securities and Exchange Commission's website. We encourage you to review these documents carefully. Additionally, certain information contained in this webcast relates to or is based on studies, publications, surveys and other data obtained from third-party sources and the company's own estimates and research. While the company believes these third-party sources to be reliable as of the date of this presentation, it does not independently verify and makes no representation as to the adequacy, fairness, accuracy or completeness of or that any independent source of verified any information obtained from third party source. Any data discussed regarding clinical trials and progress are considered preliminary and subject to change. Joining us on the call from Moleculin's leadership team are Walter Klemp, Chairman and Chief Executive Officer; Dr. John Paul Waymack, Senior Chief Medical Officer; and Jonathan Foster, Executive Vice President and Chief Financial Officer. I would now like to turn the call over to Walter Klemp, Chairman and CEO. Wally, please proceed.
Walter Klemp: Thanks, Jenene, and welcome, everyone, to our year-end recap and pipeline update. We have some very exciting progress to talk about today. And because of that, we will primarily focus on our AML second line strategy and the significant opportunity we believe this represents. As we review the activities of 2023 and the data that we are just now announcing, it becomes increasingly clear that anthracycline that is, remain perhaps the most critical component of treatment for AML and STS. For too long, though, the limitations of anthracyclines have prevented a majority of patients from benefiting. Annamycin has changed that and for the first time ever, we're showing a viable pathway to enable that underserved majority to benefit from anthracyclines. It's for this reason that we won't be focusing on the rest of our development pipeline today, other than to say that preclinical work continues to position both our stat 3 inhibitors and our metabolic inhibitors for continued outside investment that only helps Moleculin investors. The primary focus of this call and the updates we expect to provide over the coming months are squarely on Annamycin and even more specifically on the treatment of relapsed or refractory AML. And for good reason, a lot of small biotechs frankly, would give anything to have the data we just announced. Annamycin was able to generate a 60% CRC rate in second line patients. And that includes a 50% CR rate in combination with another 10% CRi. Our conservative estimate says that Annamycin should be able to more than double the number of patients achieving complete remission, as compared with all of the approved targeted therapies combined. This is possible in part because of Annamycin's complete lack of cardiotoxicity. We've treated 82 subjects so far across multiple studies and have yet to see any indication of cardiotoxicity What is important here is that all of this puts us on course to begin a pivotal registration study this year with the potential for securing an accelerated approval pathway from regulators. Look, this is a fundamentally different company than most of you on this call invested in. Candidly, even compared with just a few short months ago, we are now Phase 3 ready. We have data that outperforms every asset approved in AML and in a space where lesser assets have sold for billions. And we have established what we believe is a pathway to approval. Annamycin is a remarkable next generation treatment. Its lack of cardiotoxicity combined with its greater potency and lack of cross-resistance with currently prescribed anthracyclines truly puts it in a class by itself. And while this is true for a wide range of potential indications, it's especially meaningful in AML. The AML treatment landscape is complicated. And it's easy to lose sight of just how big the unmet need remains. We estimate that currently in the US, almost 60% of AML patients remain without a viable treatment option that could cure their disease or provide lasting remission. And that's despite all of the recent advances in targeted therapies. While we don't have time to explore this in detail today, it's very important for investors to understand why and how significant the unmet need still is. This is so important, in fact, that we produced a short video taking you through this analysis. The link to that video is shown here. And it's also right on the landing page of our website. If you are currently an investor or considering investment in Moleculin, you owe it to yourself to watch this short six minute video. And because the unmet need is so great, a lot of recent new drug approvals have been allowed on the basis of some pretty low performance numbers. Of the five targeted therapies that have been approved, they've done so on the basis of an average 21% CR rate. What we just announced is more than double that number but the difference is even greater than that. The average 21% CR rate only applies to the few patients that have - that happen to have the required targeted gene mutation. And that leaves 53% of AML patients out in the cold. In comparison, we've been treating all comers with Annamycin, regardless of gene mutation or prior therapy. And this is where Annamycin really shines compared with all of the currently approved second line therapies. The orange bars on this chart show the CR rates documented for each existing therapy. The blue bars weight those CR rates for the actual percentage of AML patients that can benefit because they happen to have the required gene mutation. And when you add them all together, it reveals that only 13% of all second line patients will achieve a CR as a result of current targeted therapies. But since Annamycin is an all comers drug, there's no reduction from weighting. Instead, 100% of the CR rate should be expected for all second line patients. And that means our 50% CR rate is multiple times greater than the expected benefit from all targeted therapies combined. And if you're thinking that the relatively low performance bar set by targeted therapies means they don't have much market value, well, think again. In 2021, Servier, a French mid pharma company, paid $2 billion for the combination of [IDHIFA] and TIBSOVO, two drugs that together are expected to produce complete responses in just 4% of the entire population of second line AML patients. We are currently showing a performance from Annamycin that is more than 10 times that number. And if you think that's an outlier, consider that our performance numbers in second line are better than Venetoclax's numbers in first line patients where you would expect higher performance. Yet, Venetoclax generates $2 billion a year in revenue for AbbVie (NYSE:ABBV). And let's not forget that Jazz Pharma paid $1.5 billion for VYXEOS where, again, we believe our performance numbers are much greater. Any way you look at it, we believe the efficacy numbers we are sharing with you today support an eventual exit for Moleculin shareholders that will be measured in the billions. And again, this is just AML. As we said before, our preclinical data suggests Annamycin should also be beneficial in a wide range of other indications, potentially addressing 10 times as many patients as both AML and STS combined. Now keep in mind our opening slide. Anthracyclines remain a cornerstone of chemotherapy in many of the worst cancers. And an anthracycline that has demonstrated a lack of cardiotoxicity could be a game changer for these cancers, especially in children where the current anthracyclines may cure their disease only to limit their lives because of the damage done to their hearts. With that as an overview, let me now hand the call over to Dr. Paul Waymack, our Senior Chief Medical Officer, to dive a bit deeper into the data. Paul?
Paul Waymack: Thank you, Wally. The next slide summarizes the three clinical trials we have conducted in patients with AML. In our MB-104 clinical study, we dosed six patients with Annamycin at either 100 or 120 milligrams per meter square. The reason for the low dosing was FDA's concern about possible cardiotoxicity. We identified no cardiotoxicity in the study, but we did achieve one CRi despite the extremely low dose of Annamycin. Our next clinical trial MB-105, treated refractory and relapsed AML patients who had an average of four prior treatment regimens. They were treated with Annamycin as monotherapy in the study in cohorts with dosages ranging from 120 to 240 milligrams per meter squared dosing regimen, plus efficacy we had seen in our animal studies, when Annamycin was combined with and Cytarabine. We elected to stop dose escalation, and to proceed to our current trial, which would combine Annamycin with and Cytarabine. Our combination Annamycin plus Cytarabine clinical trial, that is MB-106, has now enrolled 20 patients. This includes three patients for whom this is first line, 10 patients for whom it is second line therapy, and seven patients for whom it is third line or beyond. Among all patients enrolled in the study, 18 are now available for efficacy. Among these evaluable patients, the rates of CRc, that is combined CR plus CRi, is 39%. But the remaining two patients, one only began treatment last week and thus should not be undergoing bone marrow efficacy evaluations for at least two more weeks. And the other has a bone marrow with too little post chemotherapy, repopulation of the marrow to be currently evaluable. But he is currently being evaluated for possible bone marrow transplantation. Now we also have an 11% PR rate in this population. But most importantly, among patients for whom combination therapy is used as second line therapy, the CRc rate is 60% and the PR rate is 10%. The next slide, describes all the patients who achieved a CR or CRi to-date in our MB-106 study. As you can see, six of the seven patients received Annamycin as second line therapy, since we don't count maintenance therapy as a second line therapy. You will also note that we have one death from pneumonia, which occurred in the CRi patient. This unfortunate case occurred at a site, where they did not follow the accepted standards of care, for antimicrobial prophylactic therapy in leukemia patients. As soon as we identified this problem, the site was informed of this issue, and they are now utilizing the standard of care threatened by leukemia medical societies. I would next like to discuss the cardiotoxicity issue with anthracyclines in more detail. The FDA has set limits for the total amount of anthracyclines that a patient may receive over a lifetime. This ranges from 450 to 550 milligrams per meter square, depending upon the anthracycline utilized. As you can see from the slide, among patients who reach this level, the risk of any cardiac event is 65% and the risk of developing heart failure, that is the heart's pumping ability being significantly impaired, is 3.8%. Among patients who receive from 600 to 850 milligrams per meter square, the risk of any cardiac event rises to 100%, and the risk of developing heart failure is 8.3%. Because of these cardiac problems with other anthracyclines, we have serially monitored multiple parameters of cardiac function in all patients, in all of our anthracycline - Annamycin clinical trials. This has included serial EKGs, troponin concentrations, and troponins are a blood marker for acute cardiac toxicities, and ejection fractions, which is a measure of how efficiently the heart is pumping blood. These data have been reviewed by an independent cardiologist with expertise in the field of drug-induced cardiotoxicities. To-date, he has found no evidence of any cardiotoxicity in any of the patients treated with Annamycin. Finally, I would like to move on briefly to discuss our soft tissue sarcoma data. Our MB-107 study, is a dose escalation study in patients with soft tissue sarcoma with pulmonary metastases, in patients who have had at least one prior therapy. We finished enrollment in this study some time ago. However, we are continuing to follow these patients since most of them are still alive. As you can see in the column on the far right, among patients treated using the dosing regimen of 330 milligrams per meter square or less, which we believe will be our dosing regimen for any pivotal trial, and who had one or two prior therapies, our median progression-free survival, is now over three months. And we have not yet reached our median overall survival since the majority of the patients who were treated are still alive. We will continue to follow these patients, until we reach our median overall survival. Thank you. And I will now turn the presentation over to Jon.
Jonathan Foster: Thanks, Paul. We ended the year with roughly $24 million in cash on hand, sufficient to take us into the fourth quarter of this year. Keep in mind that this takes into account significant cash outlay, specifically in Q3, in Q4, for preparation to commence our AML pivotal registration study, which Paul and Wally have just discussed. On a post-split basis, our market cap as of mid-March was roughly $20 million, 22 million, with a weekly average trading volume of 55,000 shares with approximately 2.2 million shares outstanding, including pre-funded warrants that number increases to 2.4 million shares. Regarding the reverse split, given our clinical and regulatory progress, it is critical we meet the minimum $1 bid price to keep our NASS active. As we work wholeheartedly, we believe all such housekeeping items need to be in order as we prepare for a transformation into a pivotal stage development company. We continue to monitor the short positions by brokers, and we have reached out to one broker, notifying them of such shorting imbalances. A significant portion of our daily trading volume is shorting. We believe, we have the opportunity to successfully break this trading pattern with our progress in Annamycin, as we move forward in 2024. As you can see, 2024 is shaping up to be a very exciting year for Moleculin. As Wally and Paul have just discussed, we're moving forward in our clinical progress with Annamycin in 2024, with the following plans. Completing the MB-106 AML trial with first and third line subjects, and concluding the study. Taking the second line data that Paul just discussed, and holding the end of Phase 2 meeting, with the regulatory bodies here in the U.S. and in Europe. Taking that feedback and initiating a pivotal study with Annamycin on AML. With STS, we're looking to close out the current trial, as Paul just mentioned, and then moving forward with an investigator led, and funded trial. As we have concluded 2023, our year of data, we look forward to moving Moleculin into a pivotal study during 2024. Wally?
Walter Klemp: Thanks, Jon. Well, I'd like to close, with where I began today's presentation. With the observation that the most important cancer therapy, for both AML and STS continues to be in Anthracycline. And we are now providing the data showing that Annamycin has the potential to finally bring the benefit of Anthracyclines, to a majority of these patients. As a bottom line summary, we are now Phase 3 ready. We have data that outperforms every asset approved in AML. And we're in a space where lesser assets recently sold for $2 billion. And we have what we believe is an established pathway to approval. In our view, the gap between these realities and where our market cap is today can no longer be justified. We believe once the market awakens to this new reality, a more appropriate trading range will be established. And this isn't just talk. I've been investing my own after tax dollars in Moleculin stock, because of my belief in what I'm saying. In fact, I've personally invested over $300,000 over the last 16 months. And the rest of our management team has been investing right alongside me. We are believers and we are committed, to making this a success. From here, you can expect several things from us in the near future. One is, the formation of a larger and more focused science advisory board, to help guide our pathway to new drug approval. We've now shared this data with some of the most recognized and respected key opinion leaders in the global AML community. In every case, they have agreed with our assessment that there is a significant unmet need, that our efficacy numbers, if we produced in our pivotal trial, should support new drug approval, and that they would use Annamycin in their practice once approved. We'll be announcing SAB appointments in the coming weeks, and I'm confident you will be impressed with their world-class credentials. Another is a formal presentation of the final data at a prestigious conference, which we expect to be announcing soon. Also, we continue to make progress in establishing the market exclusivity of annamycin and hope to release news on that subject as well. And finally, we are preparing to meet with FDA, to discuss this data and establish a concrete approval - pathway for Annamycin that we hope to announce this summer. Until then, I encourage everyone to dig into our data. Look, until now, there has been far too much speculation and not enough facts. That changed with our most recent announcement. We could not be more proud of what we have accomplished, and we couldn't be more excited, for what is about to unfold. Thank you very much.
Operator: Thank you. [Operator Instructions] Our first question come from the line of Jonathan Aschoff with ROTH MKM. Please proceed with your questions.
Jonathan Aschoff: Thank you, guys. Good morning, and congrats on the progress, for sure. What is the final patient number for first-line patients in this new Phase 2 cohort? And what do you need to see in that population, to make the decision to go forward with a pivotal first-line trial?
Walter Klemp: Let me clarify, because we think our, let's say our first pivotal registration trial, the trial we'll use for new drug approval, will be on second-line patients, not first-line patients.
Jonathan Aschoff: Oh, for sure. But then the Phase 3 that you're talking about, what do you need to see in the new cohort?
Walter Klemp: So you're talking about the Phase 3 confirmatory. Right, right, right. So, Paul, let me…
Jonathan Aschoff: So what do you need to see in the Phase 2 first-line patients to make that decision to go forward with that trial?
Walter Klemp: Exactly. Let me hand that, Paul, over to you. You're closest to all those numbers.
Paul Waymack: Yes. As Wally mentioned, we anticipate going to the FDA with second-line therapy as their initial indication. We would, however, perform a first-line study to get an additional indication. That would be coming after our initial approval for second-line. Excuse me. We would anticipate the first-line would be a randomized trial, compared to probably a different anthracycline, to show that we are at least non-inferior and potentially superior. As far as patient numbers…
Jonathan Aschoff: However, in the trial…?
Paul Waymack: The patient numbers would be dependent upon the data we get as our current or 106 trial is finished. As was mentioned, 106 is completed for second-line, but we have only enrolled three first-line patients to-date. We're continuing to enroll them. And when we get the numbers from all the first-line patients in 106 that would be compared to the literature. And that would allow us to do power factor calculations for the number of patients required for a pivotal trial comparing us to, say, [Dana Rubison]
Jonathan Aschoff: Okay. So how many - let's break it down. How many first-line patients do you intend to enroll in 106 in the Phase 2 portion?
Paul Waymack: We are currently at three. It will be driven by the data. If we get very good results quickly, there will be no need to go further. I can see us stopping at six or seven, or going further. Right now, we only have two available, one is CR and one who has progressive disease. Third one was dosed last week. But we will just have to watch the data as they come in.
Jonathan Aschoff: Okay. Then what's the efficacy bogey? What's the CR bogey that you're looking for to say, yes, this is contender, worthy of running a Phase 3 trial in just first-line patients?
Paul Waymack: It would probably be in the 40% range, around 40%.
Jonathan Aschoff: Okay. And certainly, if you don't do this trial, you must do a confirmatory in second-line, yes?
Paul Waymack: It depends on how the meeting with FDA goes. If we are allowed to do a single-arm study under accelerated approval, then we would need a confirmatory trial. If we are required to do a randomized trial as their second-line therapy study, then a confirmatory trial might not be required. That's one reason why we plan to go and meet with the FDA, sometime by beginning of summer.
Jonathan Aschoff: Thank you. That was helpful. Why not just first-line anyway? Because this drug looks obviously safer. It certainly looks no less effective. And it's not some novel agent that docs have to get their mind around to wonder, what can I do with my patient? I mean, so why not a push in first-line now?
Paul Waymack: That's a good question. And the reason is regulatory time to approval. If we go in first-line, there are a number of drugs approved for first-line. The FDA has a different standard than for second-line, whereas Wally mentioned, right now, most patients with needing second-line therapy, they don't have any options that are good. They don't have any approved options. The five drugs approved, are for a minority of patients. So there is this unmet medical need out there, which is why the FDA cuts a different standard, which is why, as Wally mentioned, FDA approved those five drugs on what we considered limited data. And that's why we're going here first, because the amount of data that would be required, and data means the number of patients in time, will be far less than first-line therapy. And we're eager to get this thing to market as soon as possible, and thus take the second line as their initial indication and then move on to first-line to broaden the market share.
Walter Klemp: It's really about managing cost, time, and risk, right? Look, if we were Pfizer (NYSE:PFE), we probably would do exactly as you're describing, right? But we're not. And so, what Paul's just described is a dramatic, if we get what we want with FDA, is a dramatic reduction in the number of patients, and therefore the time it takes and cost it takes, for us to get there, okay.
Jonathan Aschoff: Okay. And so is it fair to say that the STS trial, I believe you had said, it's kind of now in that basket along with the lung mets from TNBC and [RSGC] and the liver mets from pancreatic cancer, it's a upon external help, we'll carry that forward and we're going to focus on AML. That's the message?
Walter Klemp: That's a reasonable takeaway. And I'll just give you a little bit of encouragement there. The leading sarcoma experts in Europe have looked at this data. And basically have indicated their strong interest, to run a trial they will fund, to position Annamycin for first-line treatment in soft tissue sarcoma. So - there's a lot of these externally funded trials take a while to get off top of dead center. But I'm just telling you the momentum appears to be there that they like the numbers, they think it should be positioned for first-line, and they want to pay for a trial.
Jonathan Aschoff: That sounds great. Thank you very much, guys.
Walter Klemp: Yes. Yes.
Operator: Thank you. Our next question has come from the line of Vernon Bernardino with H.C. Wainwright. Please proceed with your questions.
Walter Klemp: Hi Vernon.
Vernon Bernardino: Hi, Wally. Hi, Jon and Dr. Waymack. We haven't met yet, but congrats to all on the impressive results. I apologize, I have a cold, so I sound like Barry White. Anyway, I do have questions as far as the Phase 3 dose. They are quite impressive. One thing I was wondering, you have not seen any safety issues so far, and that is fantastic. I was just wondering what, if anything you could share that the FDA has any thoughts regarding that dose, because conceivably you could actually dose higher, and pardon me, I'm not an oncologist, to try to get even more efficacy out of Annamycin. What are your thoughts there, and anything you could share as far as feedback from the FDA?
Walter Klemp: Yes, so Vernon, you're right to ask that question. Look, generically speaking, especially as it relates to anthracyclines, the mindset for 40 years has been you go to the maximum, because you're trying to stop this cancer in its tracks, and you're willing to tolerate a lot of patient discomfort and even patient risk for the sake of beating the cancer. But Paul, you and I talked a lot about the optimum dose, and I think Vernon would love to hear what you have to say about the strategy behind dosing here.
Paul Waymack: Yes, and I agree with both of you. Generally, you keep going up and up and up. The reason we stopped was when we were getting CR rates of 60%, CR plus PR of 70%, and no toxicity, and when, as Wally described, the competition is in the 20% range, you reach the point where you start thinking, well, what more would I achieve at the risk of starting to get significant toxicity? So the clinical team's decision was, look, these results are far beyond what we imagined. As far as efficacy, toxicity is not there. Let's not try to improve on it, or if I can quote an old Virginia saying, when you're riding secretariat, don't get off. So, we got to this 230, 240. The results were really great, and I said, let's not try to go any further. This is working more than we ever imagined. Let's go with this.
Vernon Bernardino: So conceivably, you have this dose, go through a Phase 3 trial, and it doesn't prevent you from going to a higher dose in a post-approval trial?
Paul Waymack: Correct.
Vernon Bernardino: All right. Very exciting.
Paul Waymack: But again - as we mentioned, our number one goal is to get to an NDA as soon as possible and as cheaply as possible. We found what we thought was a safe, effective dose. We hope to get confirmation from the FDA sometime June or so, and then proceed forward.
Vernon Bernardino: Thank you very much. This is impressive data, and that's really the only one question I had. Thank you for taking it.
Paul Waymack: Thanks, Vernon.
Operator: Thank you. There are no further questions at this time. And with that, I would like to close the call out for today. You may disconnect at this time. We appreciate your participation, and I wish you a great day. Thanks, folks.
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