On Friday, H.C. Wainwright maintained a Buy rating on shares of Entera Bio (NASDAQ:ENTX), with a price target of $10.00. The firm's stance comes after Entera Bio, in collaboration with OPKO Health (NASDAQ:OPK), announced earlier this week positive top-line results from their research on a novel oral treatment for obesity and metabolic disorders.
The collaborative research focuses on combining OPKO's long-acting oxyntomodulin (OXM) analog with Entera's N-Tab technology to develop the first oral dual agonist GLP-1/glucagon peptide. This potential once-daily treatment aims to address obesity, metabolic, and fibrotic disorders. OXM is a peptide hormone that originates in the small intestine, known for its appetite suppression and weight loss induction properties.
Entera Bio and OPKO Health have successfully completed in vivo proof-of-concept pharmacokinetic and pharmacodynamic (PK/PD) studies using rodent and pig models. The studies achieved their objectives, demonstrating significant systemic exposure to oral OXM after a single dose in both animal models.
The analyst from H.C. Wainwright reiterated the positive outlook based on these findings, confirming the Buy rating and the 12-month price target for Entera Bio's stock. The continued development of this oral therapy could represent a significant advancement in the treatment of obesity and related disorders.
In other recent news, Entera Bio Ltd . and OPKO Health, Inc. reported positive preliminary results from their joint research into an orally delivered treatment for obesity and related metabolic disorders. The study focused on a long-acting oxyntomodulin (OXM) analog combined with Entera's N-Tab™ technology.
In vivo studies in rodent and pig models indicated significant systemic exposure and a favorable pharmacokinetic profile for the oral OXM after a single dose. In a glucose tolerance test on rats, oral OXM significantly reduced plasma glucose levels post-glucose administration compared to a placebo, supporting the continued development of the treatment.
Simultaneously, Entera Bio's shareholders approved key proposals, including the election of Miranda Toledano and Yonatan Malca to the company's Board of Directors for a three-year term. The shareholders also approved a one-time compensation grant for CEO Miranda Toledano, revised compensation terms for non-executive directors, and an amendment to the company's 2018 Equity Incentive Plan, which includes an increase in the number of shares issuable by 1,788,515 shares.
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