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Stifel raises Aclaris Therapeutics target to $3 on program focus

EditorLina Guerrero
Published 11/06/2024, 01:08 PM
ACRS
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On Wednesday, Stifel, a financial services company, updated its assessment of Aclaris Therapeutics (NASDAQ:ACRS), increasing the price target on the stock to $3.00 from the previous $1.00. The firm maintained its Hold rating on the shares. The adjustment comes as Aclaris shifts its attention to its ATI-2138 program, which targets ITK/JAK3. Proof of Concept (PoC) data from an open-label study in Atopic Dermatitis is anticipated in the first half of 2025.

The management team at Aclaris expects that the upcoming dataset will guide the future direction of the program. This could potentially expand the drug's use to other conditions, as evidenced by Pfizer (NYSE:PFE)'s ritlecitinib, which has shown promise in treating Alopecia Areata and Vitiligo. Like ritlecitinib, ATI-2138 inhibits JAK3 and TEC-family kinases, including ITK.

Stifel acknowledges the competitive landscape for clinical efficacy among JAK inhibitors in treating Atopic Dermatitis is challenging. However, the firm notes that there is potential for Aclaris's program to find success in other indications with emerging markets.

The financial update to Stifel's model includes additional risk-adjusted credit for Atopic Dermatitis and other potential indications. This revision reflects a growing confidence in the diversified application of Aclaris's ATI-2138 program. The company's financial position is also highlighted, with a reported $173 million in cash reserves at the end of the third quarter of 2024.

In other recent news, Aclaris Therapeutics has begun a Phase 2a trial for ATI-2138, a potential treatment for moderate-to-severe atopic dermatitis. The trial aims to assess the safety, tolerability, and efficacy of the drug over a 12-week period. H.C. Wainwright and BTIG have both reiterated a neutral stance on Aclaris Therapeutics, with H.C. Wainwright citing the need for further clarity on the company's pipeline and BTIG adopting a wait-and-see approach as the trial progresses.

In a significant financial development, Aclaris Therapeutics has sold a portion of its future royalty earnings from OLUMIANT, a treatment for alopecia areata, to OMERS, a Canadian pension plan. This deal entails an upfront payment of $26.5 million to Aclaris, with a potential additional $5.0 million contingent on specific sales milestones in 2024.

Other recent developments include Aclaris's ongoing strategic review to identify additional investment opportunities to complement its drug development pipeline. This review is being advised by Cantor Fitzgerald & Co. and DLA Piper LLP. It's worth noting that Aclaris expects to release top-line data from the Phase 2a trial of ATI-2138 in the first half of 2025.

InvestingPro Insights

Recent data from InvestingPro sheds additional light on Aclaris Therapeutics' financial position and market performance. The company's market capitalization stands at $161.95 million, reflecting its current valuation in the biotech sector. Despite the challenges noted in Stifel's analysis, Aclaris has shown remarkable short-term market performance, with a 23.33% return over the past week and an impressive 86.55% return over the last month.

InvestingPro Tips highlight that Aclaris holds more cash than debt on its balance sheet, which aligns with the article's mention of the company's $173 million cash reserves. This strong liquidity position is further supported by the fact that Aclaris's liquid assets exceed its short-term obligations. However, it's important to note that the company is quickly burning through cash, which is typical for biotech firms in the development stage.

Interestingly, 4 analysts have revised their earnings upwards for the upcoming period, suggesting some optimism about Aclaris's near-term prospects. This could be related to the anticipated Proof of Concept data for the ATI-2138 program mentioned in the article.

For investors seeking a more comprehensive analysis, InvestingPro offers 10 additional tips for Aclaris Therapeutics, providing a deeper understanding of the company's financial health and market position.

This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.

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