Pluristem (NASDAQ:PSTI) continues to advance its PLX technology platform. In a recent paper it investigated the application of these cells for their ability to inhibit tumor growth; it was found that the cells inhibit growth of a mouse xenograft of a triple-negative breast cancer cell line and induced complete remissions in three out of 10 mice. Additionally, PLX-PAD received approval for an expanded access program from the FDA, allowing it to be used to treat critical limb ischemia (CLI) outside the ongoing Phase III clinical study.
It’s a great time to be a mouse
The recent paper examined the anti-cancer activity of PLX cells induced with tumor necrosis factor alpha (TNF-α) and interferon-gamma (IFN-γ) and found they inhibit growth in 26 of 59 cancer cell lines. When a cell line for triple-negative cancer was examined in xenografts, it was found that the cells inhibited growth in vivo and induced complete remission in 3 out of 10 mice. This activity is potentially driven by a reduction in cytokines that promote tumor growth and vascularization.
To read the entire report Please click on the pdf File Below: